Many people seek healthcare support to address discomfort, such as joint and back issues. doTERRA offers a variety of products that can help support these needs, including those that:

• Promote body comfort*
• Support a healthy inflammatory response*
• Encourage immune balance and tolerance*
• Support joint health, mobility, and comfort*

But with so many options, how do you know which products to use and when?

Let's explore these five key products and how their unique cellular and molecular targets can guide your choices:

Frankincense Boswellic Acid Complex:

Frankincense Boswellic Acid Complex combines Frankincense essential oil and frankincense resin in a liquid-based microbead capsule. It contains a standardized 60% concentration of AKBA (Acetyl-11-keto-beta-boswellic acid), a compound extracted from Boswellia resin that’s known to aid a healthy inflammatory response.*

Frankincense Boswellic Acid Complex is made to support joint comfort, provide antioxidant support and protection, and—according to preclinical research—support healthy cellular function.*

Primary Benefits

• Frankincense Boswellic Acid Complex supports joint comfort and mobility.*
• Frankincense Boswellic Acid Complex promotes healthy inflammatory responses in the body and specifically in the joints.*
• Preclinical research suggests Frankincense Boswellic Acid Complex may protect against oxidative stress.*†
• A case study and preclinical research suggest Frankincense Boswellic Acid Complex may support cellular health and renewal.*†
• Preclinical research suggests Frankincense Boswellic Acid Complex may have a protective effect on the musculoskeletal and nervous systems.*†
• Genetic analysis of Boswellia serrata extract standardized to AKBA suggests Frankincense Boswellic Acid Complex regulates genes associated with promoting healthy joints and healthy inflammatory responses.*

Pathways

• Targets: 5-LOX, iNOS, leukotrienes, cytokines, and dendritic cell maturation.*
• Benefits: Promotes a healthy inflammatory response, encourages immune tolerance and balance, and maintains healthy cartilage.*
• When to use: When supporting immune balance is a priority.*

Copaiba Essential Oil:

Copaiba can help soothe anxious feelings when ingested and promotes a clear, smooth complexion when applied topically.* When taken internally, Copaiba essential oil also supports cardiovascular, immune, digestive, and nervous system health.* It helps support a healthy inflammatory response.* Copaiba can be applied directly to the mouth to cleanse and soothe the gums and oral cavity.

Though Copaiba doesn’t contain psychoactive cannabinoids, the main component, β-caryophyllene (BCP), may be neuroprotective and may have cardiovascular and immune benefits when consumed.* It’s also a powerful antioxidant.* Copaiba contains the highest levels of BCP among currently known essential oils.

An irregular cannabinoid and sesquiterpene, BCP selectively binds to CB2 receptors in the endocannabinoid system (ECS)—a signaling and regulating system comprised of enzymes, receptor sites throughout the body, and endocannabinoids produced by the body. The ECS acts as a major regulator of human health. The BCP in Copaiba binds to CB2 receptors to aid healthy immune and inflammatory responses.* It also influences multiple signaling pathways to promote healthy liver, digestive, kidney, heart, and brain function, supporting general well-being.*

Primary Benefits

• Supports cardiovascular, immune, and digestive system health when taken internally.*
• Provides powerful antioxidant properties when used internally.*
• Helps calm, soothe, and support the nervous system when taken internally.*
• Promotes clear, smooth skin and reduces the appearance of blemishes.

Pathways

• Targets: CB2R, opioid receptors, and cells in the Central and Peripheral Nervous Systems (CNS and PNS).
• Benefits: Promotes body comfort, particularly when dealing with new discomfort or discomfort involving the nervous system.*
• When to use: For occasional discomfort or when nervous system support is desired.*

Turmeric Dual Chamber Capsules:

Turmeric essential oil encourages the body’s healthy inflammatory and oxidative stress responses and may support healthy cellular function.* Turmeric oil helps with curcumin absorption. Turmeric extract contains curcuminoids, which help the body fight free radicals and protect against oxidative damage.* Assists with a healthy inflammatory response at the molecular level.*

Research shows curcuminoids have poor bioavailability, but that increases when combined with the turmerones in Turmeric essential oil. The dual chamber capsules are unique, combining key ingredients together in one convenient delivery system that results in better absorption. Unlike other products that combine turmeric extract with agents like black pepper extract, the dual chamber capsule is a more natural approach.

Alongside a healthy diet, regular exercise, and solid sleep, Turmeric Dual Chamber Capsules add a natural one-two punch in the fight against free radicals and promotion of a healthy inflammatory response.*

Primary Benefits

• Combines the complementary benefits of Turmeric essential oil and turmeric extract in a convenient capsule delivery system.*
• Supports a healthy inflammatory response in the body.*
• May help fight free radicals and protect from oxidative damage.*

Pathways

• Targets: TRPV-1, CRP, hs-CRP, TNF-α, NFkβ, iNOS, COX-2, PGE2, cytokines, MAO-A, MAO-B, and cAMP.
• Benefits: Supports a healthy inflammatory response, promotes body comfort for persistent aches, and calms the nervous system to support brain health and stabilize mood.*
• When to use: For long-lasting support, or when nervous system or mood support is needed alongside addressing support for healthy inflammatory response.*

DDR Prime:

DDR Prime is a proprietary blend of CPTG^® essential oils to support cellular health, function, and renewal.* The DDR Prime blend of Frankincense, Wild Orange, Litsea, Thyme, Clove, Summer Savory, Niaouli, and Lemongrass essential oils is shown in preclinical studies to promote a healthy response to free radicals, while also supporting healthy cellular function.* DDR Prime Essential Oil Cellular Blend Softgels are easy to swallow and provide a convenient method for consuming DDR Prime essential oil blend anytime, anywhere.

• Frankincense may promote healthy cellular function and response to free radicals when taken internally, according to preclinical research.*
• Wild Orange possesses stimulating and purifying qualities, making it ideal for supporting healthy cellular response when used internally.*
• Litsea may promote overall cellular health and function when ingested, according to experimental research.*
• Thyme may benefit the immune system when used internally, at least in part because of its thymol and carvacrol content, according to experimental research.*
• Clove may provide powerful antioxidant benefits when taken internally.*
• Summer Savory may contain antioxidant properties because of its carvacrol content when taken internally.*
• Niaouli is naturally stimulating thanks to its eucalyptol content and monoterpene composition.*
• Lemongrass promotes healthy digestion, serving as an overall tonic to bodily systems when ingested.*

Primary Benefits:

• Promotes a healthy response to free radicals*
• Supports a healthy cellular response*
• May provide immunity and cellular support with broad-spectrum activity*
• Supports a healthy response to oxidative stress, based on preclinical research.*

Pathways:

• Targets: Antioxidant pathways, including glutathione and SOD production; Nrf2, and iNOS.
• Benefits: Provides antioxidant support, protects cells, and supports healthy cellular function.*
• When to use: During periods of fatigue or physical stress when the body may require additional support. Can be paired with many other doTERRA products to enhance their cellular support.*

Deep Blue Polyphenol Complex:

Deep Blue Polyphenol Complex combines polyphenol extracts of frankincense, turmeric, green tea, ginger, pomegranate, and grapeseed. It's designed to provide soothing support to aching muscles and other occasional discomforts.*

Primary Benefits:

• Includes frankincense resin extract, which has been shown to help support muscle and joint comfort and function.*
• Helps soothe occasional aches and discomfort.*
• Contains the doTERRA Tummy Tamer blend of peppermint, ginger, and caraway seed extracts.

Pathways:

• Targets: TNF-α, PGE2, COX, LOX, TXB2, substance P, NFkβ,TRPV-1, CRP, hs-CRP, Foxp3, cytokines, leukotrienes, enzymes (transaminase, glycohydrolase, and beta-glucuronidase), mast cells, and cell-mediated immunity.
• Benefits: Promotes a healthy inflammatory response, encourages joint health, mobility, and comfort.*
• When to use: Particularly helpful for supporting joint health and comfort.*

When exploring the different options for a healthy inflammatory response, it’s important to recognize that while there is some overlap in their benefits and uses, everyone is unique, and what works best for one person may not be the same as the best option for another.

This concept, known as bio-individuality, highlights the idea that our bodies, preferences, and needs are distinct. At doTERRA, we encourage embracing this uniqueness through trial and experimentation to discover which products resonate best with your body and lifestyle. By doing so, you can tailor your experience to support your specific wellness goals in the most effective way.

Important Note: These suggestions are for general wellness and informational purposes only. Individual results may vary. It's always recommended to consult with a healthcare professional for personalized advice.

Disclaimer: This information is for general wellness and informational purposes only and does not constitute medical advice.

†More confirming clinical research is needed.

_* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.